Thiourea-Promoted Cascade Dihalogenation-Cyclization of Cyclohexadienone-Containing 1,6-Enynes
发布时间：2025-11
点击次数：
- 发布时间：
- 2025-11
- 影响因子：
- 4.4
- DOI码：
- 10.1002/adsc.202201185
- 论文名称：
- Thiourea-Promoted Cascade Dihalogenation-Cyclization of Cyclohexadienone-Containing 1,6-Enynes
- 发表刊物：
- ADVANCED SYNTHESIS & CATALYSIS
- 摘要：
- Organohalogens play an important role in the drug discovery and functional materials. However, the convenient preparation of organohalogens still remains a challenging task. Herein, we report a metal-free cascade dihalogenation-cyclization of cyclohexadienone-containing 1,6-enynes in a biodegradable solvent to generate the dibrominated cis-tetrahydrobenzofuran-5(4H)-ones and cis-dihydrobenzopyran-6(5H)-ones respectively bearing 1,4-dibromobut-1-enyl subunit in trans-trans and trans-cis form. A subgram-scale experiment and several downstream transformations are presented for elaborating the synthetic utility. Moreover, the potent anticancer activity is observed against MDA-MB-468 cells for the corresponding products.
- 第一作者：
- zhaojiaying,liaoqi,王峥涛
- 论文类型：
- 期刊论文
- 通讯作者：
- gaodingding,liqinghua,田平
- 卷号：
- 365
- 期号：
- 4
- 页面范围：
- 482-489
- ISSN号：
- 1615-4150
- 是否译文：
- 否
- 发表时间：
- 2023-02
- 他引次数：
- 3