A Highly Enantioselective Homoenolate Michael Addition/ Esterification Sequence of Cyclohexadienone-Tethered Enals via NHC Catalysis
发布时间：2025-11
点击次数：
- 发布时间：
- 2025-11
- 影响因子：
- 4.9
- DOI码：
- 10.1021/acs.orglett.2c04183
- 论文名称：
- A Highly Enantioselective Homoenolate Michael Addition/ Esterification Sequence of Cyclohexadienone-Tethered Enals via NHC Catalysis
- 发表刊物：
- ORGANIC LETTERS
- 摘要：
- Reported here is a highly enantioselective homoenolate Michael addition/esterification sequence of cyclo-hexadienone-tethered enals via N-heterocyclic carbene (NHC) catalysis, affording the enantiopure cis-hydrobenzofurans, cis-hydroindoles, and cis-hydroindenes. The NHC catalyst bearing a nitro group greatly enhances the stereocontrol, and a bulky N-aryl substituent of the triazolium salt in the catalyst is helpful for inhibiting the further aldol condensation after homoenolate Michael addition. The utility of this protocol is highlighted by a gram-scale experiment and versatile downstream transformations.
- 第一作者：
- wangyajie
- 论文类型：
- 期刊论文
- 通讯作者：
- luwenya,王雨卉,田平
- ISSN号：
- 1523-7060
- 是否译文：
- 否
- 发表时间：
- 2023-01
- 他引次数：
- 20