发布时间：

2025-11

影响因子：

5.9

DOI码：

10.1038/s42004-023-00976-5

论文名称：

A practical preparation of bicyclic boronates via metal-free heteroatom-directed alkenyl sp(2)-C?H borylation

发表刊物：

COMMUNICATIONS CHEMISTRY

摘要：

Bicyclic boronates play critical roles in the discovery of functional materials and antibacterial agents, especially against deadly bacterial pathogens. Their practical and convenient preparation is in high demand but with great challenge. Herein, we report an efficient strategy for the preparation of bicyclic boronates through metal-free heteroatom-directed alkenyl sp2-C-H borylation. This synthetic approach exhibits good functional group compatibility, and the corresponding boronates bearing halides, aryls, acyclic and cyclic frameworks are obtained with high yields (43 examples, up to 95% yield). Furthermore, a gram-scale experiment is conducted, and downstream transformations of the bicyclic boronates are pursued to afford natural products, drug scaffolds, and chiral hemiboronic acid catalysts.

第一作者：

pengpeiying

论文类型：

期刊论文

通讯作者：

liqinghua,田平

卷号：

6

期号：

1

ISSN号：

2399-3669

是否译文：

否

发表时间：

2023-08

他引次数：

3