Enantioselective Reductive Cyclization of Alkynyl-Tethered Cyclohexadienones Catalyzed by Rhodium Complexes
发布时间：2025-11
点击次数：
- 发布时间：
- 2025-11
- 影响因子：
- 5.0
- DOI码：
- 10.1021/acs.orglett.4c01276
- 论文名称：
- Enantioselective Reductive Cyclization of Alkynyl-Tethered Cyclohexadienones Catalyzed by Rhodium Complexes
- 发表刊物：
- ORGANIC LETTERS
- 摘要：
- Although various types of asymmetric cyclization reactions of 1,6-enynes have been established, simple asymmetric reductive cyclization remains underdeveloped. In this study, the enantioselective reductive cyclization of alkynyl-tethered cyclohexadienones (1,6-enynes) has been developed via a chiral pincer rhodium catalyst, affording cis-hydrobenzofurans and cis-hydroindoles with high enantioselectivities (90-99% ee). Furthermore, several synthetic applications and preliminary inhibitory activity studies against SARS-CoV-2 3CL(pro) are presented.
- 第一作者：
- wangyifan
- 论文类型：
- 期刊论文
- 通讯作者：
- tanyunxuan,田平
- ISSN号：
- 1523-7060
- 是否译文：
- 否
- 发表时间：
- 2024-07
- 他引次数：
- 3